丹參酮 A 磺酸鈉注射液對兔心肌缺血預處理后血管內皮損傷的保護作用

<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; 劉家軍1 吳 松2 李龍珠1 敖金波2<br /> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;湖北省十堰市中醫醫院消化科，十堰，442012; 2 十堰市太和醫院康復中心，十堰，442000</p> <p><b>&ldquo;上海酶聯文獻&rdquo;&nbsp;</b><strong>討論</strong></p> <p>急性心肌梗死 ( Acute Myocardial Infarction，MI) ，中醫屬心痛、胸痹范疇，其發病主要機制是氣虛血瘀，而西藥認為在冠狀動脈病變如粥樣硬化、梗阻的病理基礎上導致冠狀動脈血供急劇減少或中斷 使缺血區心肌嚴重而持久地急性缺血 。流行病學調查顯示急性心肌梗死近年來發病率明顯升高，是造成死亡的主要病因［9］，而造成心肌缺血 / 再灌注損傷主要病因是心肌缺血再灌注，其中又以心肌梗死再通手術，冠狀動脈溶栓治療及手術、冠狀動脈搭橋手術等最為嚴重 故缺血前預處理在減輕手術后心肌缺血 / 再灌注損傷的風險方面可能起到極積預防作用。研究表明，VEGF 具有促使血管內皮細胞的增殖、誘導缺血冠狀動脈血管新生并增加血管通透性的作用 。而中藥制劑丹參酮 A 磺酸鈉注射液可擴張冠狀動脈血管、增強組織耐缺氧，對缺血 / 再灌注損傷有明確的保護作用 。為探討丹參酮 A 磺酸鈉注射液對急性心肌缺血 / 再灌注損傷預處理后 VEGF 表達及心肌酶譜等的影響，我們從兔耳緣靜脈注射丹參酮 A 磺酸鈉注射液 7 d 的方法進行缺血預處理來研究其作用機制。</p> <p><br /> &nbsp;</p> <table class="MsoNormalTable" border="0" cellspacing="0" style="border-collapse: collapse; width: 482pt; margin-left: 5.6pt; border-width: initial; border-style: none; border-color: initial;"> <tbody> <tr style="height:22.7000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:56.0000pt;line-height:10.3000pt;mso-line-height-rule:exactly;">&nbsp;</p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:12.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:3.0000pt;line-height:10.3000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:9.0000pt;">丹參酮</span><span style="font-family:宋體;font-size:9.0000pt;"><o:p></o:p></span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:Arial;font-size:9.0000pt;">A</span><span style="font-family:Arial;font-size:9.0000pt;"><o:p></o:p></span></p> </td> <td width="173" valign="bottom" colspan="4" style="width:130.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;line-height:10.3000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:9.0000pt;">磺酸鈉注射液對兔缺血預處理后</span><span style="font-family:宋體;font-size:9.0000pt;"><o:p></o:p></span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:12.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:12.0000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:8.8000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:2.6000pt;text-align:right;line-height:8.3500pt;mso-line-height-rule:exactly;"><span style="font-family:Arial;font-size:9.0000pt;">3</span><span style="font-family:Arial;font-size:9.0000pt;"><o:p></o:p></span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="30" valign="bottom" style="width:23.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:7.5000pt;">&nbsp;</span></p> </td> <td width="97" valign="bottom" colspan="3" style="width:73.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="line-height:8.3500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">VEGF</span><span style="font-family:'MS PGothic';font-size:9.0000pt;">、</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">VEGFm</span><span style="font-family:'MS PGothic';font-size:9.0000pt;">Ｒ</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">NA</span><span style="font-family:Arial;font-size:9.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:4.5000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> <td width="129" valign="bottom" colspan="2" style="width:97.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New 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class="MsoNormal"><span style="font-family:'Times New Roman';font-size:3.5000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:11.1000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:26.0500pt;text-align:center;line-height:9.1500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">組別</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="129" valign="bottom" colspan="2" style="width:97.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="center" style="margin-left:30.8500pt;text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">VEGF</span><span style="font-family:宋體;font-size:8.0000pt;">(</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;Pg / mL</span><span style="font-family:宋體;font-size:8.0000pt;">)</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="30" valign="bottom" style="width:23.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:2.3500pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:31.8500pt;text-align:right;line-height:8.3000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">缺血預處理前</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="109" valign="bottom" colspan="5" style="width:82.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:4.0000pt;line-height:8.3000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">缺血預處理后</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:5.9500pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New 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;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="132" valign="bottom" colspan="2" style="width:99.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="30" valign="bottom" style="width:23.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:2.0000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:9.6000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:26.0500pt;text-align:center;line-height:8.8500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">對照組</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="132" valign="bottom" colspan="2" style="width:99.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:37.8500pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">56. 24 &plusmn; 4. 27</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">54.</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">59</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="30" valign="bottom" style="width:23.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:2.0000pt;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&plusmn; 5. 39</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:13.6500pt;"> <td width="104" valign="bottom" colspan="2" style="width:78.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:14.0500pt;text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">缺血</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;/ </span><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">再灌注組</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:11.5000pt;">&nbsp;</span></p> </td> <td width="132" valign="bottom" colspan="2" style="width:99.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:37.8500pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">55. 72 &plusmn; 3. 59</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">79.</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">86</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="37" valign="bottom" colspan="2" style="width:28.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:2.0000pt;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&plusmn; 7. 31</span>^{<span style="font-family:Arial;vertical-align:super;">*</span>}^{<span style="font-family:Arial;vertical-align:super;"><o:p></o:p></span>}</p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:11.5000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:11.9500pt;"> <td width="104" valign="bottom" colspan="2" style="width:78.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:20.0000pt;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">缺血預處理</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;A </span><span style="font-family:宋體;font-size:8.0000pt;">組</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';">&nbsp;</span></p> </td> <td width="132" valign="bottom" colspan="2" style="width:99.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:37.8500pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">57. 05 &plusmn; 4. 75</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">104.</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">59</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="77" valign="bottom" colspan="3" style="width:58.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:1.0000pt;line-height:8.9000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&plusmn; 9. 24</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:11.3500pt;"> <td width="104" valign="bottom" colspan="2" style="width:78.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" style="margin-left:20.0000pt;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">缺血預處理</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;B </span><span style="font-family:宋體;font-size:8.0000pt;">組</span><span style="font-family:宋體;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.5000pt;">&nbsp;</span></p> </td> <td width="132" valign="bottom" colspan="2" style="width:99.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:37.8500pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">58. 47 &plusmn; 4. 73</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">107.</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">97</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="77" valign="bottom" colspan="3" style="width:58.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" style="margin-left:1.0000pt;line-height:8.3000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&plusmn; 10. 48</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:9.3000pt;"> <td width="88" valign="bottom" style="width:66.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="16" valign="bottom" style="width:12.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:2.0000pt;mso-line-height-alt:0pt;"><span style="font-family:Arial;font-size:5.0000pt;">*</span><span style="font-family:Arial;font-size:5.0000pt;"><o:p></o:p></span></p> </td> <td width="21" valign="bottom" style="width:16.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="18" valign="bottom" style="width:14.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="13" valign="bottom" style="width:10.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="30" valign="bottom" style="width:23.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> </tr> <tr style="height:9.2000pt;"> <td width="338" valign="bottom" colspan="8" style="width:254.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:16.0000pt;line-height:9.2500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">注: 與對照組比較，</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;P </span><span style="font-family:'MS PGothic';font-size:8.0000pt;">＜</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;0. 05</span><span style="font-family:宋體;font-size:8.0000pt;">;</span><span style="font-family:Arial;font-size:8.0000pt;">&nbsp;</span><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">與缺血</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;/ </span><span style="mso-spacerun:'yes';font-family:宋體;font-size:8.0000pt;">再灌注組比較，</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;P </span><span style="font-family:'MS PGothic';font-size:8.0000pt;">＜</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;0. 05</span><span style="font-family:'MS PGothic';font-size:8.0000pt;">。</span><span style="font-family:'MS PGothic';font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="6" valign="bottom" style="width:5.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;">&nbsp;</span></p> </td> <td width="40" valign="bottom" style="width:30.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> </tbody> </table> <p>&nbsp;</p> <p>現代醫學證實，在正常生理代謝狀態下，機體中氧自由基生成與清除及血管內皮功能均維持著動態平衡，當機體發生病理改變如心肌組織由于缺血 / 再灌注時，組織缺血缺氧會造成清除自由基的酶 ( 總超氧化物歧化酶) 活性下降，脂質過氧化反應加劇造成血管內皮細胞嚴重損傷，此時心肌酶譜明顯異常，如血清 T-SOD、LDH 及 CK-MB 水平在缺血預處理后明顯降低，MDA 大量釋放于血液而導致異常增高，是 診 斷 心 肌 敏 感 度 和 特 異 度 較 高&ldquo;金標準&rdquo;。在缺血 / 再灌注中 VEGF 作為一種高度特異性的促血管生長因子也因缺血刺激而出現增高以彌補心肌缺血缺氧。由于 VEGF 具有促進血管內皮細胞增殖遷移再生、誘導多種血管活性物質合成。</p> <p>&nbsp;</p>